喹硫平与奥氮平治疗老年脑器质性精神障碍的临床疗效以及安全性分析

作者单位:112000 辽宁 铁岭,铁岭心理卫生医院

 老年脑器质性精神障碍;喹硫平;不良反应;生活质量

Clinical Efficacy and Safety of Quetiapine and Olanzapine in the Treatment of Organic Mental Disorders in the Elderly
HAN Feng

(Tieling Mental Health Hospital, Tieling 112000, Liaoning Province, China)

 Elderly Organic Mental Disorder; Quintiapine; Adverse Reactions; Quality of Life

DOI: 10.3969/j.issn.1672-7185.2020.06.020

备注

 目的  探讨喹硫平与奥氮平治疗老年脑器质性精神障碍的临床效果以及不良反应。方法  选取2018年5月—2019年5月在铁岭心理卫生医院精神科住院的78例患有脑器质性精神障碍的老年患者,随机分为喹硫平组和奥氮平组各39例。两组患者在治疗原发病的基础上分别给予喹硫平和奥氮平口服,比较治疗前及治疗后的1周、2周、4周以及8周时两组患者临床症状及日常生活能力改善情况,统计治疗期间不良反应发生率。结果  两组患者用药总有效率差异无统计学意义( P>0.05);两组治疗后的简明精神病评定量表评分差异无统计学意义(P>0.05);治疗4周及8周后,喹硫平组日常生活能力评分低于奥氮平组,差异有统计学意义(P<0.05)。奥氮平组用药不良反应发生率为17.95%,高于喹硫平组的5.13%,差异无统计学意义(P>0.05)。结论  喹硫平与奥氮平治疗老年脑器质性精神障碍的疗效相当,但采用喹硫平治疗的患者生活质量更高且不良反应率更低,值得临床应用。
 Objective  To investigate the clinical effects and adverse reactions of quetiapine and olanzapine in the treatment of organic mental disorders in the elderly. Methods  A total of 78 elderly patients with organic mental disorders were randomly divided into quetiapine group and olanzapine group, 39 cases in each group. The two groups were given quetiapine and olanzapine orally on the basis of treatment of primary disease. The clinical symptoms and improvement of daily living ability of patients between the two groups were compared before treatment and at 1, 2, 4 and 8 weeks after treatment, and the incidence of adverse reactions during treatment was counted. Results  No significant difference was found in the total effective rate between the two groups(97.44% in quetiapine group and 94.87% in olanzapine group) (P>0.05). The scores of the concise psychiatric rating scale after treatment were decreased in the two groups, but the difference between the two groups was not significant (P>0.05). At 4 weeks and 8 weeks after treatment, the daily living ability score of quetiapine group was significantly lower than that of olanzapine group (P<0.05). Compared with the olanzapine group (17.95%), quetiapine group (5.13%) showed no statistical significance (P>0.05). Conclusion  The efficacy of quetiapine and olanzapine in the treatment of organic mental disorders in the elderly is similar, but the patients treated with quetiapine have higher quality of life and lower rate of adverse reactions, which are safe and effective, worthy of clinical application.