达格列净对2型糖尿病伴代谢综合征患者血糖 血压和血脂的调节作用

作者单位:111000 辽宁 辽阳,辽阳市第五人民医院

 达格列净;糖尿病;2型;代谢综合征;血糖;血压;血脂

The Regulatory Effect of Dagglitazine on Blood Glucose, Blood Pressure and Blood Lipid in Patients with Type 2 Diabetes Mellitus Combined with Metabolic Syndrome
WANG Hao

(The Fifth People’s Hospital of Liaoyang, Liaoyang 111000, Liaoning Province, China)

 Dagglitazine; Diabetes; Type 2; Metabolic Syndrome; Blood Glucose; Blood Pressure; Blood Lipid

DOI: 10.3969/j.issn.1672-7185.2020.06.013

备注

 目的  观察达格列净对2型糖尿病( T2D M )患者血糖、血脂、血压的综合控制情况。方法  选择辽阳市第五人民医院2018—2019年收治的T2D M伴代谢综合征患者100例,随机分为对照组和观察组各50例。两组均常规采用降压、调脂等综合方案,对照组采用二甲双胍控制血糖,观察组采用达格列净控制血糖,比较两组治疗效果。结果  经过3个月治疗后,观察组F PG、餐后2 h血糖、糖化血红蛋白、收缩压、舒张压和甘油三酯变化值均大于对照组,差异有统计学意义(P<0.05)。结论  达格列净在调节T2DM患者血糖基础上,可能对TG产生一定的调节作用;此外,达格列净具有血压改善能力,较为适合T2DM伴代谢综合征患者群体。
 Objective  To observe dagglitazine in the comprehensive control of blood glucose, blood lipid and blood pressure in patients with type 2 diabetes mellitus (T2DM). Methods  A total of 100 T2DM patients with metabolic syndrome admitted in our hospital from 2018 to 2019 were randomly divided into control group and observation group, with 50 cases in each group. Both groups adopt antihypertensive and lipid-regulation scheme. The control group adopt metformin to control blood sugar, and the observation adopt dagglizine to control blood sugar. The treatment effect was compared between two groups. Results  After 3 months of treatment, FPG, blood glucose, glycosylated hemoglobin, systolic blood pressure, diastolic blood pressure and triglyceride in the observation group were significantly higher than those in the control group (P<0.05). Conclusion  On the basis of regulating blood glucose of T2DM patients, dagglitazine may have a certain regulatory effect on TG. In addition, dagglitazine has the ability of improving blood pressure, which is more suitable for T2DM patients with metabolic syndrome.