[1]盛一洁.血清胃蛋白酶原和胃泌素水平检测评估早期胃癌风险的应用研究[J].中国实用乡村医生杂志,2019,26(12):39-41.[doi:10.3969/j.issn.1672-7185.2019.12.013 ]
 SHENG Yijie.Application of Serum Pepsinogen and Gastrin Levels in Assessing the Risk of Early Gastric Cancer[J].Chinese Practical Journal of Rural Doctor,2019,26(12):39-41.[doi:10.3969/j.issn.1672-7185.2019.12.013 ]
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血清胃蛋白酶原和胃泌素水平检测评估早期胃癌风险的应用研究()
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《中国实用乡村医生杂志》[ISSN:1672-7185/CN:21-1502/R]

卷:
26
期数:
2019年12期
页码:
39-41
栏目:
临床研究
出版日期:
2019-12-15

文章信息/Info

Title:
Application of Serum Pepsinogen and Gastrin Levels in Assessing the Risk of Early Gastric Cancer
文章编号:
 1672-7185(2019)12-0039-03 
作者:
盛一洁
作者单位:116033 辽宁 大连,大连市中心医院健康医学中心
Author(s):
SHENG Yijie
(Department of Health Medical Center, Dalian Municipal Central Hospital, Dalian 116033, Liaoning Province, China)
关键词:
 胃癌早期胃蛋白酶原胃泌素风险
Keywords:
Gastric Cancer Early Stage Pepsinogen Gastrin Risk
分类号:
 R446.1 
DOI:
10.3969/j.issn.1672-7185.2019.12.013
文献标志码:
 A
摘要:
 目的 探讨健康人群血清胃蛋白酶原、胃泌素和幽门螺杆菌抗体水平检测评估早期胃癌风险的应用研究。方法 回顾性分析2017年6月—2019年4月大连市中心医院健康医学中心接诊的532例胃部疾病患者。抽取空腹外周静脉血,应用荧光免疫层析法检测P GⅠ、P GⅡ和G-17水平。结果 依据胃镜和病理检查,将受试者分为胃癌组和非胃癌组,胃癌组患者血清PGⅠ低于非胃癌组,PGⅡ高于非胃癌组,胃癌组患者G-17水平高于非胃癌组,差异均具有统计学意义(P<0.05)。结论 血清PG和G-17水平,可作为胃癌癌前状态的潜在早期检测靶点,当PGⅠ下降,G-17升高时,建议进一步检查。
Abstract:
Objective To explore the application of serum pepsinogen, gastrin and Helicobacter pylori antibody levels in assessing the risk of early Gastric cancer in healthy population. Methods A retrospective analysis was conducted in 532 patients with gastric diseases admitted, which were recruited in the health medical center, Dalian Municipal Central Hospital from June 2017 to April 2019. Fasting peripheral venous blood was collected and the levels of PGⅠ, PGⅡ and G-17 were detected by fluorescence immunochromatography. Results According to gastroscopy and pathological examination, the subjects were divided into gastric cancer group and non-gastric cancer group. Serum PGⅠ in gastric cancer group was significantly lower than that in non-gastric cancer group, and PGⅡ and G-17 were significantly higher than those in non-gastric cancer group (P<0.05). Conclusion Serum levels of PG and G-17 can be used as potential early detection targets for precancerous state of gastric cancer. Further examination is recommended when PGⅠ decreases and G-17 increases.

参考文献/References:

[1] 李夏,于红刚.内镜诊断早期胃癌的新进展[J].海南医学院学报,2019,25(5):392-395.
[2] 白慧霞.中国胃癌发病率及死亡率研究进展[J].临床医药文献电子杂志,2019,6(7):192.
[3] 赵忠武.胃蛋白酶和胃泌素17及HP-IGG筛查在慢性萎缩性胃炎和胃癌中的应用价值[ J].中国卫生工程学,2018,17(5):736-738.
[4] 冯娟.血清胃蛋白酶原与幽门螺旋杆菌筛查对胃癌早期诊断的临床价值分析[J].实用临床医药杂志,2018,22(19):21-24.
[5] 嵇贝纳,冯珍,程中华,等.外周血PG和G17水平联合 H p -I GG抗体检测对老年胃癌及癌前病变的诊断价值[J].中国肿瘤临床与康复,2018,25(6):648-650.
[6] 林玄威,陈革,杨河.胃泌素-17与胃蛋白酶原对原发性胃癌诊断效果及感染的影响[J].中华医院感染学杂志,2018,28(12):1786-1790.
[7] 贾宾,刘菁,孟令江,等.血清胃泌素17及胸苷激酶1的水平变化在胃癌诊断中的价值研究[J].检验医学与临床,2018,15(8):1125-1127,1131.
[8] 魏华,张蕾蕾,陈若洋,等.靶向活检联合PGⅠ、PGⅡ、G-17和H p I GG在慢性萎缩性胃炎和胃癌中的诊断意义[J].社区医学杂志,2018,16(8):54-56.
[9]李道娟,梁迪,靳晶,等.上消化道恶性肿瘤流行病学趋势[J].肿瘤预防与治疗,2018,31(1):62-68.

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备注/Memo

备注/Memo:
收稿日期:2019-07-09)
【基金项目】 2018年大连市科技创新基金项目,项目编号:2018J13SN129

更新日期/Last Update: 2019-12-31