[1]林长亮 冯星火.中性粒细胞明胶酶相关载脂蛋白、肾损伤分子-1及胱抑素-C对ICU脓毒症患者并发急性肾损伤的诊断效能[J].中国实用乡村医生杂志,2020,27(05):54-56.[doi:10.3969/j.issn.1672-7185.2020.05.019 ]
 LIN Changliang,FENG Xinghuo.Diagnostic Efficacy of NGAL, KIM-1 and Cys-C in Patients with Sepsis Complicated with Acute Renal Injury in ICU[J].Chinese Practical Journal of Rural Doctor,2020,27(05):54-56.[doi:10.3969/j.issn.1672-7185.2020.05.019 ]
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中性粒细胞明胶酶相关载脂蛋白、肾损伤分子-1及胱抑素-C对ICU脓毒症患者并发急性肾损伤的诊断效能()
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《中国实用乡村医生杂志》[ISSN:1672-7185/CN:21-1502/R]

卷:
27
期数:
2020年05期
页码:
54-56
栏目:
临床研究
出版日期:
2020-05-15

文章信息/Info

Title:
Diagnostic Efficacy of NGAL, KIM-1 and Cys-C in Patients with Sepsis Complicated with Acute Renal Injury in ICU
文章编号:
 1672-7185(2020)05-0054-03 
作者:
林长亮 冯星火
作者单位:110016 沈阳,辽宁省人民医院重症医学科
Author(s):
LIN Changliang FENG Xinghuo
(Department of Critical Care Medicine, The People’s Hospital of Liaoning Province, Shenyang 110016, Liaoning Province, China)
关键词:
 脓毒症并发症肾损伤急性中性粒细胞明胶酶相关载脂蛋白肾损伤分子-l胱抑素-C
Keywords:
 Sepsis Complication Renal Injury Acute Neutrophil Gelatinase Related Apolipoproteins Renal Injury Molecule-l Cystatin-C
分类号:
 R44 
DOI:
10.3969/j.issn.1672-7185.2020.05.019
文献标志码:
 A
摘要:
 目的 探讨中性粒细胞明胶酶相关载脂蛋白(NGAL)、肾损伤分子-l(KIM-1)及胱抑素-C(Cys-C)对ICU脓毒症患者并发急性肾损伤(AKI)的诊断效能。方法 选择2018—2019年辽宁省人民医院收治的脓毒症患者114例,依据患者是否出现AKI分为损伤组61例和非损伤组53例。以双抗体夹心酶标免疫分析法检测患者不同时间点NGAL、KIM-1和Cys -C水平,评估三者对AKI的诊断效能。结果 两组不同时间点NGAL、KIM-1和Cys -C水平差异均有统计学意义(P<0.05)。三种标志物单独检测的诊断效能以KIM-1最佳,三种标志物联合检测的诊断效能优于单一标志物检测。结论 血清NGAL、KIM-1和Cys -C均可早期预测脓毒症患者出现AKI,推荐三种标志物联合检测,以提高诊断效能。
Abstract:
Objective To compare the diagnostic efficacy of Neutmphil Gelatinase Associated Lipocalin (NGAL), Kidney Injury Molecule-l (KIM-1) and Cystatin-C (Cys-C) in predicting acute renal injury (AKI) in patients with sepsis in intensive care unit (ICU). Methods A total of 114 patients with sepsis admitted to The People’s Hospital of Liaoning Province from 2018 to 2019 were divided into injury group (61 cases) and non injury group (53 cases) according to whether there is AKI. The levels of NGAL, KIM-1 and Cys-C at different time points were detected by double antibody sandwich enzyme immunoassay, and their diagnostic efficacy for AKI was compared. Results There were significant differences in NGAL, KIM-1 and Cys-C levels between the two groups at different time points (P < 0.05). Among the three markers, KIM-1 is the best, but the combined detection efficiency of three markers is significantly better than single marker. Conclusion Serum NGAL, KIM-1 and Cys-C can predict the occurrence of AKI in sepsis in the early stage. We recommend the combined detection of three markers to improve the diagnostic efficiency.

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备注/Memo

备注/Memo:
收稿日期:2020-01-02)
【通信作者】 冯星火,Email:wh640219@163.com

更新日期/Last Update: 2020-06-16