[1]王旭.扶正消癥生髓汤辅助治疗晚期恶性肿瘤化疗后骨髓抑制效果观察[J].中国实用乡村医生杂志,2020,27(05):51.[doi:10.3969/j.issn.1672-7185.2020.05.018 ]
 WANG Xu.Effect of Fuzheng Xiaozheng Shengsui Decoction on Myelosuppression after Chemotherapy for Advanced Cancer[J].Chinese Practical Journal of Rural Doctor,2020,27(05):51.[doi:10.3969/j.issn.1672-7185.2020.05.018 ]
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扶正消癥生髓汤辅助治疗晚期恶性肿瘤化疗后骨髓抑制效果观察()
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《中国实用乡村医生杂志》[ISSN:1672-7185/CN:21-1502/R]

卷:
27
期数:
2020年05期
页码:
51
栏目:
论著
出版日期:
2020-05-15

文章信息/Info

Title:
Effect of Fuzheng Xiaozheng Shengsui Decoction on Myelosuppression after Chemotherapy for Advanced Cancer
文章编号:
 1672-7185(2020)05-0051-04 
作者:
王旭
作者单位:124000 辽宁 盘锦,盘锦市中医医院药械科
Author(s):
WANG Xu
(Department of Pharmacy and Instruments, Panjin Hospital of Traditional Chinese Medicine, Panjin 124000, Liaoning Province, China)
关键词:
 肿瘤恶性晚期化疗骨髓抑制扶正消癥生髓汤
Keywords:
 Tumor Malignancy Advanced Stage Chemotherapy Myelosuppression Fuzheng Xiaozheng Shengsui Decoction
分类号:
 R73 
DOI:
10.3969/j.issn.1672-7185.2020.05.018
文献标志码:
 A
摘要:
 目的 探讨扶正消癥生髓汤辅助治疗晚期恶性肿瘤化疗后骨髓抑制的效果。方法 选择2016—2019年盘锦市中医医院收治的晚期肿瘤患者110例,随机分为观察组和对照组各55例。两组根据化疗后白细胞和血小板水平采用重组人粒细胞集落刺激因子和(或)重组人血小板生成素治疗,观察组在此基础上加用扶正消癥生髓汤。比较两组化疗前后不同时间点血白细胞、中性粒细胞和血小板变化情况。结果 两组化疗后1周血白细胞、中性粒细胞和血小板水平呈下降趋势,化疗后2周和3周呈上升趋势。两组化疗后2周和3周血白细胞、中性粒细胞和血小板水平差异有统计学意义(P<0.05)。结论 扶正消癥生髓汤辅助治疗晚期恶性肿瘤化疗后骨髓抑制患者,能够进一步提高外周血血细胞水平,较单纯应用西药效果更佳。
Abstract:
Objective To explore the effect of Fuzheng Xiaozheng Shengsui Decoction in the treatment of myelosuppression after chemotherapy for advanced cancer. Methods A total of 110 patients with advanced tumor admitted to Panjin Hospital of Traditional Chinese Medicine from 2016 to 2019 were randomly divided into observation group and control group, 55 cases in each group. Both groups were treated with recombinant human granulocyte colony stimulating factor (G-CSF) and (or) recombinant human thrombopoietin (rhTPO) according to the levels of WBC and PLT after chemotherapy. On this basis, the observation group was treated with Fuzheng Xiaozheng Shengsui decoction. The changes of WBC, neutrophils and PLT at different time points before and after chemotherapy were compared between the two groups. Results The level of WBC, neutrophils and PLT decreased in one week after chemotherapy, and increased in two and three weeks after chemotherapy. There were significant differences in the levels of WBC, neutrophils and PLT between the two groups at two and three weeks after chemotherapy (P < 0.05). Conclusion Fuzheng Xiaozheng Shengsui decoction can further improve the level of peripheral blood cells in patients with myelosuppression after chemotherapy for advanced cancer, which is better than Western medicine alone.

参考文献/References:

[1]陈芳芳,王英浩,王玲玲,等.中医治疗乳腺癌放化疗后骨髓抑制临床进展[J].世界中医药,2019,14(8):1974­1978.
[2] 刘高伟,王雪梅,徐娟.G-CSF/GM-CSF序贯治疗宫颈癌化疗后骨髓抑制的效果及预后观察[J].解放军医药杂志,2019,31(10):36-39.
[3] 林洪生,张英.从“扶正培本”到“固本清源”:中医药治疗肿瘤理论的传承与创新[J].中医杂志,2016,57(4):295-298.
[4] 孙国明.补血益肾汤对化疗后骨髓抑制发生率的影响[J].中国实用医药,2018,13(17):102-104.
[5]蔡智慧,李卉,东丽,等.聚乙二醇化重组人粒细胞集落刺激因子预防恶性肿瘤化疗Ⅳ度骨髓抑制27例[J].安徽医药,2019,23(11):2287-2290.
[6] 钱娟,陆伟,杨力,等.重组人血小板生成素联合激素及环孢素A治疗免疫相关性血细胞减少症20例近期疗效及安全性[J].中华血液学杂志,2017,38(12):1078­1081.
[7]袁艺萍,任春梅.扶正消癥生髓汤联合重组人粒细胞集落刺激因子对上皮性卵巢癌化疗后骨髓抑制及外周血象的影响[J].现代中西医结合杂志,2019,28(33):3707-3711.
[8] 王竹林,曲红卫,王秀芳,等.自拟抗癌固本消癥汤辅助化疗治疗老年Ⅳ期卵巢癌临床研究[J].国际中医中药杂志,2019,41(10):1043-1048.
[9]张余转,游海星,郑雪莹.热毒宁注射液联合阿奇霉素对G-CSF、对粒细胞集落刺激因子及炎症因子水平的影响[J].国际检验医学杂志,2019,40(13):1640­1643.
[10]杨金乐,王庆海,徐瑾,等.不同剂量丙种球蛋白与rhTPO治疗难治性血小板减少性紫癜的免疫学及氧化应激反应比较[J].河北医药,2019,41(16): 2469­2472.
[11]张森,何威华,华松,等.扶正消瘤汤对食管癌患者放疗前后临床症状、细胞免疫功能及外周血细胞凋亡的影响[J].陕西中医,2018,39(11):1511-1514.

相似文献/References:

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备注/Memo

备注/Memo:
收稿日期:2020-01-15)

更新日期/Last Update: 2020-06-16