[1]吴淑敏 刘嘉雯 张世倡.剖宫产围手术期应用不同抗菌药物方案预防术后腹部切口感染的效果及其成本-效果分析[J].中国实用乡村医生杂志,2020,27(05):47-50.[doi:10.3969/j.issn.1672-7185.2020.05.017 ]
 WU Shumin,LIU Jiawen,ZHANG Shichang.The Analysis of Effect and Cost-effectiveness of Different Antibiotics to Prevent Postoperative Abdominal Incision Infection in the Perioperative Period of Cesarean Section[J].Chinese Practical Journal of Rural Doctor,2020,27(05):47-50.[doi:10.3969/j.issn.1672-7185.2020.05.017 ]
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剖宫产围手术期应用不同抗菌药物方案预防术后腹部切口感染的效果及其成本-效果分析()
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《中国实用乡村医生杂志》[ISSN:1672-7185/CN:21-1502/R]

卷:
27
期数:
2020年05期
页码:
47-50
栏目:
论著
出版日期:
2020-05-15

文章信息/Info

Title:
The Analysis of Effect and Cost-effectiveness of Different Antibiotics to Prevent Postoperative Abdominal Incision Infection in the Perioperative Period of Cesarean Section
文章编号:
 1672-7185(2020)05-0047-04 
作者:
吴淑敏1 刘嘉雯2 张世倡3
作者单位:1.528308 广东 佛山,南方医科大学顺德医院临床药学科;2.南方医科大学顺德医院附属陈村医院药剂科;3.南方医科大学顺德医院附属杏坛医院药剂科
Author(s):
WU Shumin1 LIU Jiawen2 ZHANG Shichang3
(1. Department of Clinical Pharmacy, Shunde Hospital of Southern Medical University, Foshan 528308, Guangdong Porvince, China; 2.Department of Pharmacy, Chencun Hospital Affiliated to Shunde Hospital of Southern Medical University; 3.Department of Pharmac
关键词:
 剖宫产术后切口感染预防抗菌药物成本-效果
Keywords:
 Cesarean Section Postoperative Incision Infection Prevention Antibiotics Cost-effectiveness
分类号:
 R71 
DOI:
10.3969/j.issn.1672-7185.2020.05.017
文献标志码:
 A
摘要:
 目的 探讨剖宫产围手术期预防性使用不同抗菌药物方案,对预防术后腹部切口感染的效果及其成本-效果。方法 选取2019年1月1日—12月31日拟于南方医科大学顺德医院行剖宫产的160例产妇为研究对象,根据使用药物的不同分为A组(头孢呋辛+甲硝唑)、B组(头孢硫脒+甲硝唑)、C组(头孢唑林)和D组(头孢替唑)4组各40例。比较4组手术情况,围术期炎症因子如干扰素(INF-γ)、降钙素原(PCT)、C反应蛋白(CRP)变化情况,医疗费用、术后腹部切口感染发生情况。以医疗费用为成本(C),术后无腹部切口感染为效益(E),采用成本效益比(C/E)比较分析4组预防术后腹部切口感染的成本-效果。结果 4组手术指标如手术时间、术中出血量、术后住院时间,以及医疗费用和围术期炎症因子水平比较,差异均无统计学意义(P>0.05)。A组、B组、C组和D组术后腹部切口感染发生率分别为7.50%、10.00%、5.00%和15.00%,差异无统计学意义(P>0.05)。4组中C/E值C组最低,其次为A组和B组,D组最高,差异有统计学意义(P<0.05)。结论 剖宫产围手术期应用不同抗菌药物方案均可有效控制炎症反应和预防术后腹部切口感染的发生,其中以头孢唑林方案的成本-效果最佳。
Abstract:
Objective To explore the effect and cost-effectiveness of prophylactic use of different antimicrobial agents in the perioperative period of cesarean section on the prevention of postoperative abdominal incision infection. Methods A total of 160 cases of parturients who intended to perform cesarean section in Shunde Hospital of Southern Medical University from January 1st, 2019 to December 31st , 2019 were selected as the objects. According to the different drugs used, they were divided into group A (Cefuroxime combined with Metronidazole), group B (Cefathiamidine combined with Metronidazole), group C (Cefazolin) and group D (Clozacam) with 40 cases in each group. The changes of inflammatory factors such as interferon (INF -γ), procalcitonin (PCT), C-reactive protein (CRP), medical expenses and postoperative abdominal incision infection were compared among the four groups. The cost-effectiveness ratio (C/E, C: cost of medical expense; E: effectiveness without postoperative abdominal incision infection) was used to analyze the cost-effectiveness of four groups to prevent postoperative abdominalincision infection. Results There was no significant difference between the four groups in terms of operation time, intraoperative bleeding volume, postoperative hospital stay, medical expenses and perioperative inflammatory factors (P > 0.05). The incidence of postoperative abdominal incision infection in group A, B, C and D was 7.50%, 10.00%, 5.00% and 15.00%, respectively, with no significant difference (P > 0.05). Among the four groups, the C/E value of group C was the lowest, followed by group A and group B, and group D was the highest (P < 0.05). Conclusion Different antimicrobial regimens can effectively control the inflammatory reaction and prevent the postoperative infection of abdominal incision. The cost-effectiveness of cefazolin is the best.

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备注/Memo

备注/Memo:
收稿日期:2020-03-25)
【基金项目】佛山市卫生和计生局医学科研课题立项(项目编号:20190372),项目名称:顺德区产科剖宫产围手术期预防性应用抗菌药物不同方案的成果-效果分析

更新日期/Last Update: 2020-06-16